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Bioscience, Biotechnology, and Biochemistry Volume 65, 2001 - Issue 2
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Original Articles

Apoptosis-inducing Activity of High Molecular Weight Fractions of Tea Extracts

Sumio HAYAKAWASchool of Food and Nutritional Sciences, University of Shizuoka
,
Takashi KIMURASchool of Food and Nutritional Sciences, University of Shizuoka
,
Kouichi SAEKISchool of Food and Nutritional Sciences, University of Shizuoka
,
Yu KOYAMASchool of Food and Nutritional Sciences, University of Shizuoka
,
Yutaka AOYAGIThird Division, Internal Medicine, Niigata University School of Medicine
,
Tadataka NOROGraduate School of Nutritional and Environmental Sciences, University of Shizuoka
,
Yoshiyuki NAKAMURASchool of Pharmaceutical Sciences, University of Shizuoka
&
Mamoru ISEMURASchool of Food and Nutritional Sciences, University of Shizuoka
 show all
Pages 459-462 | Received 15 Aug 2000, Accepted 05 Oct 2000, Published online: 22 May 2014
 
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Abstract

High molecular weight fractions of green tea, black tea, oolong tea, and pu-erh tea were found to induce apoptosis in human monoblastic leukemia U937 cells by examination of their ability to inhibit cell proliferation and to induce apoptotic body formation and DNA ladder formation. These tea fractions were also shown to induce apoptosis in stomach cancer MKN-45 cells. In addition to known antitumor-promoting activity of tea high molecular weight fractions, their apoptosis-inducing activity may contribute to cancer chemopreventive effects of tea.

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