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Bioscience, Biotechnology, and Biochemistry Volume 66, 2002 - Issue 7
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Original Articles

Effect of Tea Catechins on Cellular Lipid Peroxidation and Cytotoxicity in HepG2 Cells

Chikako MURAKAMIFaculty of Nutrition, Kobe Gakuin University Arise 518, Ikawadani-cho, Nishi-ku, Kobe 651-2180, Japan
,
Yuki HIRAKAWAFaculty of Nutrition, Kobe Gakuin University Arise 518, Ikawadani-cho, Nishi-ku, Kobe 651-2180, Japan
,
Hiroshi INUIFaculty of Applied Biological Chemistry, Osaka Prefecture University Gakuencho 1-1, Sakai, Osaka 599-8531, Japan
,
Yoshihisa NAKANOFaculty of Applied Biological Chemistry, Osaka Prefecture University Gakuencho 1-1, Sakai, Osaka 599-8531, Japan
&
Hiromi YOSHIDAFaculty of Nutrition, Kobe Gakuin University Arise 518, Ikawadani-cho, Nishi-ku, Kobe 651-2180, Japan
Pages 1559-1562 | Received 12 Nov 2001, Accepted 20 Feb 2002, Published online: 22 May 2014
 
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Abstract

Tea catechins inhibited TBARS accumulation in HepG2 cells, the order of effectiveness being (−)-epigallocatechin gallate (EGCG)>(−)-epigallocatechin (EGC)≥(−)-epicatechin gallate (ECG)>(−)-epicatechin (EC). EGCG and EGC protected the depletion of α-tocopherol in the cells, and the glutathione content was enhanced by all four catechins. Moreover, all four catechins suppressed the formation of glutathione disulfide and the activation of glutathione peroxidase induced by tert-butylated hydroperoxide.

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