5-Bromo-2′-deoxyuridine Efficiently Suppresses Division Potential of the Yeast Saccharomyces cerevisiae

Michihiko FUJIIDivision of Biochemistry, Yokohama City UniversityMaioka-cho 641-12, Totsuka-ku, Yokohama 244-0813, Japan

Hisasi ITODivision of Biochemistry, Yokohama City UniversityMaioka-cho 641-12, Totsuka-ku, Yokohama 244-0813, Japan

Tsutomu HASEGAWADivision of Biochemistry, Yokohama City UniversityMaioka-cho 641-12, Totsuka-ku, Yokohama 244-0813, Japan

Toshikazu SUZUKIDivision of Biochemistry, Yokohama City UniversityMaioka-cho 641-12, Totsuka-ku, Yokohama 244-0813, Japan

Noritaka ADACHIDivision of Biochemistry, Yokohama City UniversityMaioka-cho 641-12, Totsuka-ku, Yokohama 244-0813, Japan;Division of Molecular Cell Genetics, Kihara Institute for Biological Research and Graduate School of Integrated Science, Yokohama City UniversityMaioka-cho 641-12, Totsuka-ku, Yokohama 244-0813, Japan

Dai AYUSAWADivision of Biochemistry, Yokohama City UniversityMaioka-cho 641-12, Totsuka-ku, Yokohama 244-0813, Japan

Abstract

We established a thymidine-auxotrophic strain of the yeast Saccharomyces cerevisiae to examine biological effects of thymidine analogues. 5-Bromo-2′-deoxyuridine efficiently suppressed the division potential of yeast showing morphology similar to senescent cells.

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5-Bromo-2′-deoxyuridine Efficiently Suppresses Division Potential of the Yeast Saccharomyces cerevisiae

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5-Bromo-2′-deoxyuridine Efficiently Suppresses Division Potential of the Yeast Saccharomyces cerevisiae

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