Advanced search
Publication Cover
Bioscience, Biotechnology, and Biochemistry Volume 66, 2002 - Issue 4
Journal homepage
154
Views
53
CrossRef citations to date
0
Altmetric
Original Articles

Conjugated Linoleic Acid Reduces Body Fats and Cytokine Levels of Mice

Asuka AKAHOSHIFaculty of Environmental and Symbiotic Sciences, Prefectural University of Kumamoto3-1-100 Tsukide, Kumamoto 862-8502, Japan
,
Yuki GOTOFaculty of Environmental and Symbiotic Sciences, Prefectural University of Kumamoto3-1-100 Tsukide, Kumamoto 862-8502, Japan
,
Kayoko MURAOFaculty of Environmental and Symbiotic Sciences, Prefectural University of Kumamoto3-1-100 Tsukide, Kumamoto 862-8502, Japan
,
Tomoko MIYAZAKIFaculty of Environmental and Symbiotic Sciences, Prefectural University of Kumamoto3-1-100 Tsukide, Kumamoto 862-8502, Japan
,
Masao YAMASAKIDivision of Bioresource and Bioenvironmental Sciences, Graduate School, Kyushu UniversityHigashi-ku, Fukuoka 812-8581, Japan
,
Michiko NONAKADivision of Bioresource and Bioenvironmental Sciences, Graduate School, Kyushu UniversityHigashi-ku, Fukuoka 812-8581, Japan
,
Koji YAMADADivision of Bioresource and Bioenvironmental Sciences, Graduate School, Kyushu UniversityHigashi-ku, Fukuoka 812-8581, Japan
&
Michihiro SUGANOFaculty of Environmental and Symbiotic Sciences, Prefectural University of Kumamoto3-1-100 Tsukide, Kumamoto 862-8502, Japan
 show all
Pages 916-920 | Received 26 Oct 2001, Accepted 17 Dec 2001, Published online: 22 May 2014
 
Sample our Physical Sciences journals, sign in here to start your FREE access for 14 days

Abstract

In order to discover the effect of CLA on the body fat size and serum cytokine levels, four groups of male mice were fed diets containing either 1% linoleic acid (LA) or conjugated linoleic acid (CLA) with or without 0.2% sesamin for 8 weeks. The weight gain and feed efficiency were significantly lower in the CLA groups. CLA significantly reduced relative weights (g/100 g body weight) of epididymal and perirenal adipose tissues, in particular the former. Concentrations of serum TNF-α and leptin were significantly reduced by dietary CLA. Sesamin did not show additional effects in all of these parameters. There was a positive correlation between cytokine production and body-fat reducing potential of CLA. These results indicated that mice appeared to be a hyperresponder to dietary CLA insofar as the reduction of body fat size is concerned.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related Research Data

Dietary conjugated linoleic acid reciprocally modifies ketogenesis and lipid secretion by the rat liver.
Source: Wiley
Nutraceutical Functions of Sesame: A Review
Source: Informa UK Limited
Mechanisms of Action of Conjugated Linoleic Acid: Evidence and Speculation
Source: Wiley
EFFECTS OF CONJUGATED LINOLEIC ACID ISOMERS ON SERUM TUMOR NECROSIS FACTOR‐A CONCENTRATION IN MICE
Source: Wiley
Safety of conjugated linoleic acid (CLA) in overweight or obese human volunteers
Source: Wiley
Modulation of macrophage cytokine production by conjugated linoleic acids is influenced by the dietary n-6:n-3 fatty acid ratio
Source: Elsevier BV
Acute reduction of serum leptin level by dietary conjugated linoleic acid in Sprague-Dawley rats
Source: Elsevier BV
Conjugated linoleic acid supplementation for 1 y reduces body fat mass in healthy overweight humans
Source: Oxford University Press (OUP)
Conjugated linoleic acid supplementation in humans: effects on body composition and energy expenditure.
Source: Wiley
Dietary Lipids and Health
Source: John Wiley & Sons, Inc.
Investigation of the potential of conjugated linoleic acid (Cla) to cause peroxisome proliferation in rats.
Source: Elsevier BV
Conjugated linoleic acid supplementation in humans: effects on circulating leptin concentrations and appetite.
Source: eScholarship, University of California
Sesamin, a sesame lignan, is a potent inducer of hepatic fatty acid oxidation in the rat.
Source: Elsevier BV
Leptin levels in human and rodent : Measurement of plasma leptin and ob RNA in obese and weight-reduced subjects
Source: Springer Science and Business Media LLC
Effect of conjugated linoleic acid on body composition in mice
Source: Wiley
Isomers of Conjugated Linoleic Acid Differ in Their Effects on Angiogenesis and Survival of Mouse Mammary Adipose Vasculature
Source: Oxford University Press (OUP)
Conjugated linoleic acid supplementation reduces adipose tissue by apoptosis and develops lipodystrophy in mice.
Source: American Diabetes Association
Leptin levels reflect body lipid content in mice: Evidence for diet-induced resistance to leptin action
Source: Springer Science and Business Media LLC
MULTIPLE RANGE AND MULTIPLE F TESTS
Source: JSTOR

Linking provided by 
Download PDF

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.