Change in the Concentration of Vitamins C and E in Rat Tissues by Paraquat Administration

Abstract

Paraquat causes lung injury by oxidative stress. After 48 h of intraperitoneal administration of paraquat (50 mg/kg of body weight) to rats, the vitamin C concentration in the lungs was significantly decreased, while lung vitamin E content was increased after 12 h. These results indicate that vitamin C directly reflected the oxidative stress in the lungs.

• oxidative stress
• paraquat
• radical
• vitamin C
• vitamin E