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Abstract
In female SD rats that were injected with 4 g/kg BW ethanol p.o. followed by a 5 mg/kg BW lipopolysaccharide (LPS) i.v. injection, serum glutamic pyruvic transaminases (GPT) activity increased to about eight times that of normal rats. In this model, rats that had been fed a diet containing 1% Hydrangeae Dulcis Folium (HDF) extracts for fifteen days showed significantly lower serum GPT activity (380.0±58.2 IU/l) than the control group (3527.0±774.1 IU/l). HDF's efficacy was far superior to milk thistle in this model (2950.0±915.9 IU/l).
When mouse macrophages were treated with HDF extracts at 50 μg/ml, TNF-α production induced by LPS was suppressed to about 10% of the control. Rat serum TNF-α levels induced by LPS was decreased to 58.7% of the control by administering 1000 mg/kg BW HDF extract p.o. These results indicate that HDF prevents alcohol-induced liver injury through the inhibition of TNF-α production.