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Bioscience, Biotechnology, and Biochemistry Volume 67, 2003 - Issue 9
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Original Articles

Fosmidomycin Resistance in Adenylate Cyclase Deficient (cya) Mutants of Escherichia coli

Yoshiko SAKAMOTODepartment of Food Science and Technology, College of Bioresouce Sciences, Nihon UniversityKameino 1866, Fujisawa, Kanagawa 252-8510, Japan
,
Soichi FURUKAWADepartment of Food Science and Technology, College of Bioresouce Sciences, Nihon UniversityKameino 1866, Fujisawa, Kanagawa 252-8510, Japan
,
Hirokazu OGIHARADepartment of Food Science and Technology, College of Bioresouce Sciences, Nihon UniversityKameino 1866, Fujisawa, Kanagawa 252-8510, Japan
&
Makari YAMASAKIDepartment of Food Science and Technology, College of Bioresouce Sciences, Nihon UniversityKameino 1866, Fujisawa, Kanagawa 252-8510, Japan
Pages 2030-2033 | Received 10 Apr 2003, Accepted 16 Jun 2003, Published online: 22 May 2014
 
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Abstract

Adenylate cyclase deficient (cya) mutants of E. coli K-12 were found to be resistant to fosmidomycin, a specific inhibitor of the non-mevalonate pathway, just like to fosfomycin. E. coli glpT mutants were resistant to fosfomycin and also to fosmidomycin. This fact shows that fosmidomycin was transported inside via the glycerol-3-phosphate transporter, GlpT. DNA micro-array analysis showed that the transcription of glpT and other genes concerning glycerol utilization were highly dependent on the presence of cAMP.

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Related Research Data

Isolation of Genomic Deoxyxylulose Phosphate Reductoisomerase (DXR) Mutations Conferring Resistance to Fosmidomycin
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