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Original Articles

Synthesis and Absolute Configuration of (−)-3-Butyl-7-hydroxyphthalide, a Cytotoxic Metabolite of Penicillium vulpinum*

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Pages 2240-2244 | Received 11 Jun 2003, Accepted 07 Jul 2003, Published online: 22 May 2014
 

Abstract

Both the enantiomers as well as the racemate of 3-butyl-7-hydroxyphthalide (1) were synthesized, and the absolute configuration of the naturally occurring (−)-1 (a weakly cytotoxic metabolite of Penicillium vulpinum) was identified as S.

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