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Original Articles

Modulations of Food-derived Substances on Intestinal Permeability in Caco-2 Cell Monolayers

Pages 2297-2299 | Received 05 Jun 2003, Accepted 01 Jul 2003, Published online: 22 May 2014
 

Abstract

The effects of more than 300 kinds of food extracts on intestinal permeability were investigated in Caco-2 cells with the use of model compounds: Lucifer Yellow (LY) for the paracellular pathway, Fluorescein (FC) for the monocarboxylic acid transporter-mediated pathway, and Rhodamine 123 (RH) for the p-glycoprotein-mediated efflux pathway. With several extracts of increasing or decreasing LY permeation, increasing FC or RH permeation was also observed, indicating modulation by dietary substances in several pathways for intestinal absorption.

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