Synthesis of (3R,4S)-3,4,5-Trihydroxy-4-methylpentylphosphonic Acid as a Potential Inhibitor of the Nonmevalonate Pathway

Abstract

The nonmevalonate pathway is widely found in higher plants and in many eubacteria, including pathogenic ones, but not in mammals. Identifying a nonmevalonate pathway inhibitor would greatly contribute to the search for new herbicides and antibacterial drugs to treat, for example, malaria. We describe here the synthesis of (3R,4S)-3,4,5-trihydroxy-4-methylpentylphosphonic acid as a candidate for inhibiting MEP cytidylyltransferase, which is the third step on the nonmevalonate pathway.

• nonmevalonate pathway
• inhibitor
• drug discovery
• malaria
• MEP cytidylyltransferase