Inhibition of Osteoporosis Induced by Protein Deficient (PD) Food Intake by Active Vitamin D₃ and Vitamin K₂ in Rats

Liman SUNLaboratories of Applied Biochemistry, Faculty of Agriculture, University of the Ryukyus

Hajime TAMAKILaboratories of Applied Biochemistry, Faculty of Agriculture, University of the Ryukyus

Yutaka OHTAFaculty of Medicine, University of the Ryukyus

Naofumi KATSUYAMAFaculty of Medicine, University of the Ryukyus

Tetsuji ISHIMARUMusashi Junior High School

Isao CHINENLaboratories of Applied Biochemistry, Faculty of Agriculture, University of the Ryukyus

Abstract

Independent use of K₂ and D₃ and simultaneous application of K₂ and D₃ inhibited the development of osteoporosis caused by PD food intake. The ALP activity of urine as a marker of bone formation osteoporosis did not rise in rats fed PD foods containing D₃, K₂ or both together. Body and womb weights fell in rats fed PD foods with D₃ K₂ and both D₃, K₂. Osteoporosis caused by PD food intake found to be very similar to type II osteoporosis in respects of inhibition by D₃ and K₂ and rising urinary ALP activity.

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Inhibition of Osteoporosis Induced by Protein Deficient (PD) Food Intake by Active Vitamin D₃ and Vitamin K₂ in Rats

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Inhibition of Osteoporosis Induced by Protein Deficient (PD) Food Intake by Active Vitamin D3 and Vitamin K2 in Rats

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Inhibition of Osteoporosis Induced by Protein Deficient (PD) Food Intake by Active Vitamin D₃ and Vitamin K₂ in Rats