Prolyl Endopeptidase and Thrombin Inhibitory Diterpenoids from the Bark of Xylopia aethiopica

Noungoue Tchamo DIDEROTDepartment of Organic Chemistry, Faculty of Sciences, University of Yaounde I

Ngouela SILVEREDepartment of Organic Chemistry, Faculty of Sciences, University of Yaounde I

Amsha YASINH.E.J. Research Institute of Chemistry, International Center for Chemical Sciences, University of Karachi

Seema ZAREENH.E.J. Research Institute of Chemistry, International Center for Chemical Sciences, University of Karachi

Zelefack FABIENDepartment of Organic Chemistry, Faculty of Sciences, University of Yaounde I

Tsamo ETIENNEDepartment of Organic Chemistry, Faculty of Sciences, University of Yaounde I

M. Iqbal CHOUDHARYH.E.J. Research Institute of Chemistry, International Center for Chemical Sciences, University of Karachi

ATTA-UR-RAHMANH.E.J. Research Institute of Chemistry, International Center for Chemical Sciences, University of Karachi

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Abstract

The inhibitory effects of seven diterpenes, belonging to three different structural classes and isolated from the bark of Xylopia aethiopica, were investigated against the enzymes prolyl endopeptidase (PEP) and α-thrombin. Five compounds exhibited inhibitory activity against them.

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Prolyl Endopeptidase and Thrombin Inhibitory Diterpenoids from the Bark of Xylopia aethiopica

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Prolyl Endopeptidase and Thrombin Inhibitory Diterpenoids from the Bark of Xylopia aethiopica

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