Protective Effect of Epigallocatechin Gallate and Esculetin on Oxidative DNA Damage Induced by Psoralen Plus Ultraviolet-A Therapy

Abstract

We examined antioxidants exhibiting no effects on DNA cross-linking, which is the basis of psoralen and ultraviolet-A therapy for skin diseases, and suppressing oxidative DNA damage incidental to the therapy. Epigallocatechin gallate and esculetin effectively suppressed oxidative DNA damage with little effect on the formation of DNA cross-linking. These antioxidants might be useful in suppressing the adverse reaction induced by this therapy.

• psoralen and ultraviolet-A irradiation (PUVA)
• cross-linking
• oxidative DNA damage
• antioxidant