Dillapiol and Apiol as Specific Inhibitors of the Biosynthesis of Aflatoxin G₁ in Aspergillus parasiticus

Mehdi RAZZAGHI-ABYANEHDepartment of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo

Tomoya YOSHINARIDepartment of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo

Masoomeh SHAMS-GHAHFAROKHIDepartment of Mycology, Faculty of Medical Sciences, Tarbiat Modares University

Mohammad-Bagher REZAEEDepartment of Medicinal Plants, Institute for Research in Forests and Rangelands

Hiromichi NAGASAWADepartment of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo

Shohei SAKUDADepartment of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo

Abstract

Dillapiol was isolated from the essential oil of dill as a specific inhibitor of aflatoxin G₁ production. It inhibited aflatoxin G₁ production by Aspergillus parasiticus with an IC₅₀ value of 0.15 μM without inhibiting aflatoxin B₁ production or fungal growth. Apiol and myristicin, congeners of dillapiol, showed similar activity with IC₅₀ values of 0.24 and 3.5 μM, respectively.

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Dillapiol and Apiol as Specific Inhibitors of the Biosynthesis of Aflatoxin G₁ in Aspergillus parasiticus

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Dillapiol and Apiol as Specific Inhibitors of the Biosynthesis of Aflatoxin G₁ in Aspergillus parasiticus