Impact of Spermine on Down-Regulation of Th2 Cytokines in Peripheral Blood Mononuclear Cells from Cedar Pollinosis Subjects in Vitro

Mitsuharu MATSUMOTODairy Science and Technology Institute, Kyodo Milk Industry Co., Ltd.;Japan Collection of Microorganisms, RIKEN BioResourse Center

Hiroichi KIMATADairy Science and Technology Institute, Kyodo Milk Industry Co., Ltd.

Yoshimi BENNOJapan Collection of Microorganisms, RIKEN BioResourse Center

Shigenori KAMIOOchiai Clinic

Abstract

The effects of spermine (SPM) on the production of Th1 and Th2 cytokines using peripheral blood mononuclear cells (PBMCs) derived from cedar pollinosis subjects were investigated. Th2 cytokines produced by PBMCs stimulated by 10 μM SPM was significantly lower than that in the controls. These findings indicate that blood SPM is an important factor in the Th1/Th2 balance.

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Impact of Spermine on Down-Regulation of Th2 Cytokines in Peripheral Blood Mononuclear Cells from Cedar Pollinosis Subjects in Vitro

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Impact of Spermine on Down-Regulation of Th2 Cytokines in Peripheral Blood Mononuclear Cells from Cedar Pollinosis Subjects in Vitro

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