The Yeast Checkpoint Kinase Dun1 Downregulates DIN7 in the Absence of DNA Damage

Abstract

Yeast DIN7 is a DNA damage-inducible gene. Its expression is increased in the absence of Dun1, a DNA damage checkpoint kinase. We identified a DIN7 promoter region responsible for Dun1-mediated downregulation and found that DIN7 expression was not further increased in response to hydroxyurea in Δdun1 cells. Thus DIN7 repression by Dun1 can be released upon DNA damage.

• mitochondria
• transcriptional regulation
• DNA damaging checkpoint