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Original Articles

Anionic C-Terminal Proregion of Nematode Antimicrobial Peptide Cecropin P4 Precursor Inhibits Antimicrobial Activity of the Mature Peptide

, , , , , & show all
Pages 3281-3284 | Received 12 Jun 2008, Accepted 18 Aug 2008, Published online: 22 May 2014
 

Abstract

Recently, an anionic proregion was found to be conserved at the C terminus of the antimicrobial peptide, nematode cecropin. Our results suggest that the antimicrobial activity of mature peptide is suppressed by the proregion in its precursor and is released from inhibition after processing. Inhibition is not likely to be due to direct suppression of membrane disruption.

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