Disruption of Lipid Rafts Enhances the Effect of Lactobacilli on the Production of Tumor Necrosis Factor-Alpha in Mononuclear Blood Cells

Mario SORIACenter of Reference for Lactobacilos (CERELA-CONICET)

Mónica MECHOUDCenter of Reference for Lactobacilos (CERELA-CONICET)

Angela MARTIN DE QUEVEDOLaboratorio Quevedo

Graciela FONT DE VALDEZCenter of Reference for Lactobacilos (CERELA-CONICET)

Ana V. RODRIGUEZCenter of Reference for Lactobacilos (CERELA-CONICET)

Abstract

We investigated, to determine whether disruption of lipid rafts would influence the effect of three selected strains of Lactobacillus on TNF-alpha production by peripheral blood mononuclear cells. Two strains increased TNF-alpha production; and the third one reduced cytokine levels. Disruption of rafts changed the immunomodulatory effect of the three strains. This is the first report on a potential role of rafts in lactobacilli-cell interaction.

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Disruption of Lipid Rafts Enhances the Effect of Lactobacilli on the Production of Tumor Necrosis Factor-Alpha in Mononuclear Blood Cells

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Disruption of Lipid Rafts Enhances the Effect of Lactobacilli on the Production of Tumor Necrosis Factor-Alpha in Mononuclear Blood Cells

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