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Bioscience, Biotechnology, and Biochemistry Volume 73, 2009 - Issue 6
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Original Articles

The Augmenting Activity of 6-(Methylsulfinyl)hexyl Isothiocyanate on Cellular Glutathione Levels Is Less Sensitive to Thiol Compounds Than Its Cytotoxic Activity

Yumi KIDACHIDepartment of Clinical Pharmacy, Aomori University
,
Toshiro NOSHITADepartment of Clinical Pharmacy, Aomori University
,
Hideaki YAMAGUCHIDepartment of Pharmacy, Meijo University
,
Hironori UMETSUDepartment of Life Sciences, Junior College, Gifu Shotoku Gakuen University
,
Yoko FUKEDepartment of Health Promotion Sciences, Graduate School of Human Health Sciences, Tokyo Metropolitan University
&
Kazuo RYOYAMADepartment of Clinical Pharmacy, Aomori University;Graduate School of Environmental Sciences, Aomori University
Pages 1419-1421 | Received 07 Nov 2008, Accepted 28 Feb 2009, Published online: 22 May 2014
 
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Abstract

We analyzed the effects of thiol compounds on the biological activities of 6-(methylsulfinyl)hexyl isothiocyanate (6-MITC). Thiol compounds abolished the cytotoxic activity of 6-MITC, but did not abolish its activity augmenting cellular total glutathione levels and gamma-glutamylcysteine ligase gene expression. Thiol compounds might play an important role in the augmentation of several significant biological activities by overcoming the inherent limitations of 6-MITC.

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