Advanced search
Publication Cover
Bioscience, Biotechnology, and Biochemistry Volume 73, 2009 - Issue 4
Journal homepage
512
Views
54
CrossRef citations to date
0
Altmetric
Original Articles

Molecular Mechanism of Transcriptional Cascade Initiated by the EvgS/EvgA System in Escherichia coli K-12

Junji ITOUDepartment of Bioscience, Graduate School of Agriculture, Kinki University
,
Yoko EGUCHIDepartment of Bioscience, Graduate School of Agriculture, Kinki University
&
Ryutaro UTSUMIDepartment of Bioscience, Graduate School of Agriculture, Kinki University
Pages 870-878 | Received 10 Nov 2008, Accepted 15 Dec 2008, Published online: 22 May 2014
 
Sample our Physical Sciences journals, sign in here to start your FREE access for 14 days

Abstract

Using an EvgS-active mutant (evgS1) in combination with gene deletions, we clarified the molecular mechanism of the transcriptional cascade of acid resistance and multidrug resistance genes initiated by the EvgS/EvgA two-component system in Escherichia coli, followed by sequential induction of the transcriptional regulators, YdeO and GadE. Overexpression of EvgA, the response regulator of the EvgS/EvgA system, is known to induce the expression of a number of acid resistance and multidrug resistance genes, in which the EvgA-YdeO-GadE circuit is involved, but the role of the sensor EvgS in this circuit has remained unsolved. Our results suggest that the transcriptional cascade initiated by the EvgS/EvgA system in fact functions for acid and drug resistance in E. coli.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related Research Data

GadE (YhiE): a novel activator involved in the response to acid environment in Escherichia coli.
Source: Microbiology Society
EvgA of the Two-Component Signal Transduction System Modulates Production of the YhiUV Multidrug Transporter in Escherichia coli
Source: American Society for Microbiology
Transcriptome analysis of a two-component system
Source: Wiley
PAS domain mutants in the EvgS histidine kinase
Source: Wiley
Functional characterization in vitro of all two-component signal transduction systems from Escherichia coli.
Source: American Society for Biochemistry & Molecular Biology (ASBMB)
Introduction to bacterial signal transduction networks.
Source: Springer New York
Sigma S-dependent growth-phase induction of the csgBA promoter in Escherichia coli can be achieved in vivo by sigma 70 in the absence of the nucleoid-associated protein H-NS.
Source: Wiley
Enhance nisin yield via improving acid-tolerant capability of Lactococcus lactis F44.
Source: Springer Science and Business Media LLC
Comparative transcriptomic analysis of the multi-targeted effects of the herbal extracts against Escherichia coli O157:H7
Source: Springer Science and Business Media LLC
Transcription of emrKY is Regulated by the EvgA-EvgS Two-Component System in Escherichia coli K-12
Source: Oxford University Press (OUP)
Quinone sensing by histidine kinases
Source: Wiley
B1500, a small membrane protein, connects the two-component systems EvgS/EvgA and PhoQ/PhoP in Escherichia coli
Source: Proceedings of the National Academy of Sciences
Regulation of Acid Resistance by Connectors of Two-Component Signal Transduction Systems in Escherichia coli
Source: American Society for Microbiology
Role ofgadBCoperon in orally acquired bacteria
Source: Wiley
Overexpression of the response regulator evgA of the two-component signal transduction system modulates multidrug resistance conferred by multidrug resistance transporters.
Source: American Society for Microbiology
Alkali Metals in Addition to Acidic pH Activate the EvgS Histidine Kinase Sensor in Escherichia coli
Source: American Society for Microbiology
Phenotype MicroArray Analysis of Escherichia coli K-12 Mutants with Deletions of All Two-Component Systems
Source: American Society for Microbiology
Coping with low pH: molecular strategies in neutralophilic bacteria
Source: Oxford University Press (OUP)
Regulatory network of acid resistance genes in E. coli
Source: Wiley
GadE-dependent acid control of gadA/BC and E. coli acid resistance
Source: Wiley
Newly identified genes involved in the signal transduction of Escherichia coli K-12
Source: Elsevier BV
Transcriptional regulation of drug efflux genes by EvgAS, a two-component system in Escherichia coli.
Source: Microbiology Society

Linking provided by 
Download PDF

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.