Transient Up-Regulation of Immunity- and Apoptosis-Related Genes in Caco-2 Cells Cocultured with THP-1 Cells Evaluated by DNA Microarray Analysis

Yoko ISHIMOTODepartment of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo

Yuji NAKAIAgricultural Bioinformatics Research Unit, Graduate School of Agricultural and Life Sciences, The University of Tokyo

Hideo SATSUDepartment of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo

Mamoru TOTSUKADepartment of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo

Makoto SHIMIZUDepartment of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo

Abstract

We analyzed changes in gene expression in Caco-2 cells cocultured with THP-1 cells over time periods of 0, 1, 3, 6, 24, and 48 h using a DNA microarray. Differentially expressed genes extracted with maSigPro indicated that an early defense response and cell death occured at the same time, causing an inflammatory condition.

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Transient Up-Regulation of Immunity- and Apoptosis-Related Genes in Caco-2 Cells Cocultured with THP-1 Cells Evaluated by DNA Microarray Analysis

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Transient Up-Regulation of Immunity- and Apoptosis-Related Genes in Caco-2 Cells Cocultured with THP-1 Cells Evaluated by DNA Microarray Analysis

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