Cell Culture and Motility Study on a Polymer Surface with a Nanometer-Scaled Stripe Structure

Yasuyuki SAKAMOTODepartment of Applied Biological Chemistry, School of Agricultural and Life Sciences, The University of Tokyo

Kiichi SATODepartment of Applied Biological Chemistry, School of Agricultural and Life Sciences, The University of Tokyo;Center for NanoBio Integration, The University of Tokyo

Mitsuru ABODepartment of Applied Biological Chemistry, School of Agricultural and Life Sciences, The University of Tokyo

Takehiko TSUKAHARADepartment of Applied Chemistry, School of Engineering, The University of Tokyo

Takehiko KITAMORICenter for NanoBio Integration, The University of Tokyo;Department of Applied Chemistry, School of Engineering, The University of Tokyo

Keiko ABEDepartment of Applied Biological Chemistry, School of Agricultural and Life Sciences, The University of Tokyo

Etsuro YOSHIMURADepartment of Applied Biological Chemistry, School of Agricultural and Life Sciences, The University of Tokyo

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Abstract

We developed a large cell culture surface with a nanostripe structure by paving polydimethylsiloxane (PDMS) replicas of a glass mold. The stripe structure has a height of 180 nm and top width of 500 nm with 400-nm intervals between stripes. Human stomach cancer SH-10-TC cells cultured on the surface changed their morphology to elongated shapes parallel to the nanostripes. In addition, cell motility parallel to the stripes was greatly enhanced. These findings strongly suggest that the nanostripe structure affected the cell physiology.

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Cell Culture and Motility Study on a Polymer Surface with a Nanometer-Scaled Stripe Structure

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Cell Culture and Motility Study on a Polymer Surface with a Nanometer-Scaled Stripe Structure

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