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Original Articles

Polymorphisms in the Human Apolipoprotein E Receptor 2 Gene in Japanese Sporadic Alzheimer’s Disease Patients

, , , , , , , & show all
Pages 677-679 | Received 18 Nov 2009, Accepted 26 Dec 2009, Published online: 22 May 2014
 

Abstract

Apolipoprotein E (apoE) polymorphism is associated with onset of Alzheimer’s disease (AD). We found seven polymorphisms in apoE receptor 2 (ApoER2), an apoE-binding receptor, in Japanese sporadic AD patients, but no association of ApoER2 polymorphisms with AD. We consider that the functions of ApoER2 in the brain may be compensated for by those of other apoE-binding receptors such as VLDL receptor.

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