Abstract
The abuse of alcohol and other drugs (AOD) by youth is, once again, on the rise, emphasizing the need for prevention intervention. This article discusses the research on the prevention of substance abuse among youth who are identified as especially vulnerable to, or at high risk of, AOD abuse. The individual, interpersonal, and institutional risk factors associated with substance abuse among youth are described. Research on prevention programs for high risk youth is presented next, with a consideration of the methodological problems associated with this research. Despite the problems noted, the findings suggest there may be some effective methods of preventing substance abuse among high risk youth. The article concludes with a discussion of implications for prevention practice, as well as social policy.