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Abstract
The hypocalcaemic effect of glucagon is well documented in the literature. In this investigation the pancreatic islet cells were studied in hypocalcaemic (parathyroidectomized) and hypercalcaemic (parathyroid hormone treated) rats. Observations were made after 1 and 8 weeks of hypocalcaemia and after 3 days of hypercalcaemia. No qualitative or quantitative changes in the islet cells were observed. The results are discussed.