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Novelty: Novel 5,11-dihydro-6H-dipyrido[3,2-b:2′,3′-e][1,4]diazepin-6-one and thione derivatives useful in the treatment or prevention of HIV infection are disclosed.
Biology: The activity of the present compounds is evaluated in a reverse transcriptase inhibition assay (10 μg/ml, gives 45-100% inhibition).
Chemistry: 5-11-Dihydro-11-ethyl-5-methyl-6H dipyrido [3.2-b:2′,3′-e][1,4] diazepin-6-thione is an exemplified compound.
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