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Summary
Novelty: A hybridoma which secretes an antibody specific for the exotoxin A of Pseudomonas aeruginosa is described. The antibodies can be used for therapy of P. aeruginosa infection. The exotoxin A is a potent toxin related to diphtheria toxin and is secreted by all pathogenic strains of P. aeruginosa.
Biology: The antibody recognises an amino acid sequence from 591-613 of exotoxin A and results in neutralisation of the toxin. A human monoclonal antibody generated by EBV transformation is described.