![Sample our Bioscience journals, sign in here to start your access, Latest two full volumes FREE to you for 14 days]({"type":"image" , "src" : "/sda/5925/TOC-Subject-Sample-2021-Bioscience.jpg"})
Summary
Novelty: Novel substituted quinazolinones possessing angiotensin II (AII) antagonistic activity and useful as antihypertensive agents are disclosed. The compounds are also useful for treating congestive heart failure and in the treatment of elevated intraocular pressure.
Biology: Protocols for a receptor binding assay using a rabbit aorta membrane preparation and a bovine adrenal cortex preparation for determining AII antagonist activity are described, together with in vivo methods for evaluating antihypertensive effects in rats. Representative compounds exhibited IC50 values of less than 50 μM.
Chemistry: 2-Butyl-6-methyl-3-[(2′-(tetrazol-5-yl)biphenyl-4-yl)methyl]quinazolin-4(3H)-one is one of ninety-nine exemplified compounds.