Aminospiropiperidine quinazoline derivatives as selective inhibitors of nitric oxide synthase

Abstract

Aminospiropiperidine quinazoline derivatives are claimed as nitric oxide synthase (NOS) inhibitors. These compounds are claimed to be selective inhibitors of inducible NOS (iNOS) that may be useful for the treatment of inflammatory conditions such as osteoarthritis, rheumatoid arthritis, psoriasis or other inflammatory skin condition, inflammatory eye conditions, asthma, ulcers, Crohn’s disease, pain, septic shock, immune system disorders and vascular diseases. These compounds may selectively inhibit the neuronal NOS (nNOS) and thus may be useful in the treatment of stroke and neurodegenerative diseases. Biological results presented in this application give support to these compounds as iNOS inhibitors. All the chemical intermediates are also claimed as inhibitors of NOS without supporting data. The synthetic process for the preparation of the title derivatives is also claimed in this application.

• aminospiropiperidine
• inflammation
• nitric oxide synthase inhibitor
• quinazoline
• rheumatoid arthritis