The cloning of the human histamine H₃ receptor

Abstract

The polynucleotide sequence of the gene encoding the human histamine H₃ receptor was identified by mining expressed sequence tag (EST) libraries. The gene has been cloned and the receptor expressed in a variety of cell lines. Like other amine transmitter receptors, the cloned histamine H₃ receptor appears to be a G protein-coupled receptor (GPCR) and has been characterised in vitro using existing pharmacological tools. This invention may have many consequences for the histamine H₃ area. It has already resulted in the cloning of guinea-pig and rat histamine H₃ receptors and the use of the human receptor in high-throughput screens for the identification of potential drug candidates.

• attention-deficit hyperactivity disorder
• cloning
• GT-2331
• human histamine H3 receptor
• obesity
• Perceptin™