Novel cyclic N-hydroxamic acid inhibitors of TNF-α synthesis and MMP-13

Abstract

Three patent applications, representative of nine such applications, claim dual TACE/MMP-13 inhibitors. Some of the compounds are also potent inhibitors of MMP-1 and/or MMP-9. The majority of the claimed compounds are propynyloxyphenylsulfonamide derivatives of an α-, or ortho-, amino-N-hydroxamic acids, incorporated in most cases into a cyclic template.

• ADAM-17
• MMP-9
• MMP-13
• rheumatoid arthritis
• TACE
• TNF-α
• TNF synthesis inhibitor