Tertiary amide ureido derivatives VLA-4 antagonists

Abstract

Ureido tertiary amide derivatives are claimed as antagonists of the ₄β₁integrin receptor (VLA-4). They inhibit the binding of adhesion molecules such as VCAM-1 (vascular cell adhesion molecule-1) and fibronectin to this integrin receptor. Such compounds are useful in the treatment of a range of inflammatory diseases such as asthma.

• asthma
• integrin antagonist
• VCAM-1
• VLA-4