Abstract
In this patent, two new natural product toxins named apicularene A and apicularene B are claimed by the Society for Biotechnological Research, Germany. Also claimed are the process for isolation and purification of apicularenes from Chondromyces robustus strains and formulations containing apicularenes. Apicularene A shows high cytotoxic activity against a series of human cell lines. This cytotoxicity mainly seems to be mediated via modulation of microtubuli formation and action. New natural product toxins are of general interest in the field of cancer therapy, because they serve as lead compounds for development of new chemotherapeutic agents.