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Miscellaneous

N-substituted acetonitrile inhibitors of cathepsin L

Pages 149-152 | Published online: 25 Feb 2005
 

Abstract

These two applications claim small peptide and benzamide derivatives of acetonitrile, mostly a-substituted, as inhibitors of the Cathepsins. They are shown to be inhibitors of cathepsin L with potencies in the 40 nM range. They are claimed to be useful in treating chronic obstructive pulmonary disease (COPD) and diseases mediated by cathepsin L or cathepsin S.

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