Protein kinase inhibitors: emerging pharmacophores 1997 - 2000

Abstract

Kinase inhibition is a major area for therapeutic intervention against a variety of diseases including cancer, inflammatory disorders and diabetes. While this mode of action remains very promising at this time, it faces critical challenges, such as drug safety, and biopharmaceutical profile. This review provides an update on kinase inhibitor pharmacophores from a structural standpoint. Advances in older inhibitor classes as well as new emerging lead structures will be presented.

• angiogenesis
• cancer
• cell cycle
• inflammation
• kinase
• MAPK
• receptor kinase