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Expert Opinion on Therapeutic Patents Volume 11, 2001 - Issue 6
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Review

Anticancer titanium agents

Francesco Caruso Istituto di Strutturistica Chimica ‘G. Giacomello’, CNR, CP 10, 00016, Monterotondo Stazione, Roma, Italy. [email protected]
,
Miriam Rossi Vassar College, Department of Chemistry, Poughkeepsie, NY, 12604-0484, USA
&
Claudio Pettinari Dipartimento di Scienze Chimiche, Università di Camerino, via S. Agostino 1, 62032 Camerino, MC, Italy
Pages 969-979 | Published online: 25 Feb 2005
 
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Abstract

Most antitumour Ti compounds act on tumours in the gastrointestinal tract. Some species with increased water solubility also show activity towards breast, lung and melanoma cancers. These compounds are structurally and chemically diverse, ranging from complex salts to coordination complexes. In the former, the oxidative state can be either Ti(III) or Ti(IV); while in the latter the co-ordination number can be 4 or 6. Active 6 coordinate species can be mono- or tetranuclear compounds. This review focuses on recent progress in this promising area including clinical studies and their related patents. Additional features of this non-toxic metal, not yet described in patents, are also mentioned along with perspectives for application in cancer therapy.

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