Non-peptidic chymase inhibitors

Abstract

Human chymase is a chymotrypsin-like serine protease. Although the physiological and pathological roles of chymase have not been fully elucidated, recent studies have implicated its involvement in numerous physiological functions. Preliminary results suggest a wide therapeutic utility for chymase inhibitors in disorders such as heart failure, hypertension, chronic inflammation, allergy, dermatitis, rheumatoid arthritis and asthma. This review will focus on patent applications describing non-peptidic chymase inhibitors published within the last five years.

• cardiovascular disease
• chymase
• enzyme inhibitor
• fibrosis
• inflammatory disease
• serine protease