Amide derivatives useful for the treatment of diseases mediated by cytokines

Abstract

Two patents from AstraZeneca claim amide derivatives or ring-closed amide derivatives (in this case 3,4-dihydroquinazolin-4-ones) useful for the treatment of diseases or medical conditions mediated by cytokines. The exemplified analogues are inhibitors of MAPK and p38α, and also inhibit TNF-α production in human whole blood.

• cytokines
• IL-1
• immunoregulation
• inflammation
• MAPK
• osteoarthritis
• p38 kinase
• rheumatoid arthritis
• TNF-α