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Abstract
Nasal delivery offers a promising alternative to parenteral delivery. Prodrug strategies are usually aimed at modifying the parent drug such that favourable physicochemical and biological properties for absorption are obtained. Modulation of the drug hydrophilicity/lipophilicity or linkage of a moiety that will target membrane transporters or receptors may lead to enhanced drug absorption. A sizeable number of prodrug patents awarded in the past few years signal a high commercial potential for this approach. Novel developments include prodrug synthesis for drug delivery to the CNS via the nasal route. Prodrug modification also holds promise for intranasal delivery of anticancer drugs.