Recent progress in 5-HT₆ receptor antagonists for the treatment of CNS diseases

Abdelmalik Slassi Discovery Chemistry Department, NPS Pharmaceuticals, 6850 Goreway Drive, Mississauga, Ontario, L4V 1V7, Canada, Tel.: +1 905 677 0831; Fax: +1 905 677 9595;, E-mail: [email protected]

Methvin Isaac Discovery Chemistry Department, NPS Pharmaceuticals, 6850 Goreway Drive, Mississauga, Ontario, L4V 1V7, Canada, Tel.: +1 905 677 0831; Fax: +1 905 677 9595;, E-mail: [email protected]

Anne O’Brien Discovery Chemistry Department, NPS Pharmaceuticals, 6850 Goreway Drive, Mississauga, Ontario, L4V 1V7, Canada, Tel.: +1 905 677 0831; Fax: +1 905 677 9595;, E-mail: [email protected]

Abstract

In light of the barrage of recent reviews on 5-HT₆ receptor antagonists, this article highlights and reviews the research advances published in patent literature between January 1998 and December 2001. The article is supplemented with selected references on design, synthesis and development of novel 5-HT₆ agents to treat CNS diseases and to study and understand their mechanism and pathophysiology. Emphasis is given to recent advances in the possible involvement of 5-HT₆ serotonergic agents in the treatment of schizophrenia and depression. By no means has any attempt been made to exhaustively review the literature but rather, primary references along with citations to recent literature reviews have been included in each section.

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Recent progress in 5-HT₆ receptor antagonists for the treatment of CNS diseases

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Recent progress in 5-HT₆ receptor antagonists for the treatment of CNS diseases