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Abstract
Two related series of PDE7 inhibitors with sub-micromolar potency are claimed. These are N-phenyl-3-benzoxazol-2-ylphenylsulfonamide and N-phenyl-3-benzimidazol-2-ylphenylsulfonamide derivatives. These represent the fourth series of PDE7 inhibitors described to date and may be useful in the treatment of asthma and allergic diseases, via modulation of T cell function.