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Abstract
A method for immunotherapy of allergy is described, based on the finding that intranasal instillation of antiallergen antibodies of IgG2a isotype alleviates airway inflammation in a murine model of allergic asthma. This method, which avoids the risks of conventional vaccination strategies associated with administration of allergen, is claimed to induce a persistent conversion of pathogenic antiallergen Th2 immune response to a benign Th1 immune response.