Recent discovery and development of non-peptide vasopressin V₂ receptor agonists

Abstract

Desmopressin, 1-desamino-8-D-arginine vasopressin (DDAVP), is a peptide analogue of arginine vasopressin (AVP), which is an agonist of the AVP V₂ receptor. It is used for the treatment of central diabetes insipidus, the control of nocturnal enuresis and may also be of use for controlling nocturia. However, DDAVP is a peptide analogue with variable bioavailability, even via an intranasal route or in oral formulation. Therefore, the discovery and the development of an orally effective non-peptide V₂ agonist may be particularly useful in all respects. The continuous filing of patents since 1995 evidences the importance of this field.

• agonist
• arginine vasopressin (AVP)
• bioavailability
• diabetes insipidus
• mimic
• modulator
• nocturia
• nocturnal enuresis
• non-peptide
• orally effective
• polyuria
• receptor
• V₂ receptor
• vasopressin