Novel urea-based CCR_2B receptor antagonists

Abstract

CCR_2B receptor antagonists based upon a 1,3dimethylpyrazolo[5,4-b]pyridin-5-yl-N-phenylaminocarbonyl)carboxamide template are claimed. These represent a structurally novel class of CCR_2B receptor antagonists. They were shown to be effective in animal models of inflammatory diseases including atherosclerosis and rheumatoid arthritis. This class of antagonist defines the chemical strategy of Telik in pursuing inhibitors of the effects of MCP-1.

• atherosclerosis
• CCR_2B antagonist
• chemokine
• inflammation
• MCP-1
• rheumatoid arthritis