IgE modulation in asthma

Abstract

Asthma is a chronic inflammatory disease of the airways in which allergic mechanisms, involving antibodies of the IgE class, play an important role. A humanised anti-IgE antibody that prevents the binding of IgE to its receptors has proved effective in asthma in early clinical trials. Alternative strategies for the neutralisation or suppression of IgE are being investigated and some novel compounds and coadministration regimens have been suggested. These include the provocation of host anti-IgE immune responses and the suppression of IgE synthesis, as well as the blockade of IgE receptors. Although these routes of investigation are still at an early stage of exploration, they may produce some highly novel therapeutic agents.

• allergy
• antibodies
• asthma
• IgE