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Miscellaneous

IL-22 inhibitors to treat inflammatory disorders such as arthritis

Pages 373-375 | Published online: 02 Mar 2005
 

Abstract

IL-22 is a recently described cytokine showing 23% amino acid identity with IL-10, and which has been previously shown to induce the production of acute phase proteins in liver and pancreas, suggesting a role in inflammatory responses. This patent application claims agents that modulate IL-22 activity useful as modulators of a large panel of inflammatory disorders, including autoimmune diseases, cancer and sepsis. More particularly, anti-IL-22 antibodies are reported to inhibit arthritis in a mouse model.

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