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Miscellaneous

Indole-based CXC chemokine receptor-2 antagonists

Pages 721-723 | Published online: 02 Mar 2005
 

Abstract

Two patents claim structurally novel 4-(2-arylindol-3-yl) butanoic acid derivatives that are active as CXC chemokine receptor-2 (CXCR2) antagonists. The claimed compounds differ in the indole 5-substituent, either having a substituted phenyl ring or a nitrile group. The compounds are claimed to be useful in the treatment of a broad range of inflammatory disease.

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