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Abstract
The ryanodine receptor (RyR) is an essential element in excitation–contraction coupling. Ca2+ release from the sarcoplasmic reticulum (SR) is required for skeletal and heart muscle contraction. The inositol-1,4,5-triphosphate-receptor (IP3R) plays an important function in the signal transduction of many hormones, cytokines, growth factors and antigens, and in fertilisation. Modulators of intracellular calcium channels are used for the treatment of malignant hyperthermia associated with abnormal Ca2+ transport and may be applied in the treatment of cardiovascular and neurodegenerative disorders.