Synthetic inhibitors of yeast cyclin-dependent kinase-activating kinases as antifungal agents

Abstract

The Vertex application discloses an indeterminate number of indolizine and related heterocyclic derivatives that are claimed to be inhibitors of cyclindependent kinase (CDK)-activating kinases (CAKs), useful as antifungal agents. The GPC Biotech application discloses an indeterminate number of compounds with a phenethylazaryl ‘portion’ linked to various substituents; all claimed to be inhibitors of various fungal enzymes, particularly prenyltransferases and CAK.

• antifungal
• cyclin-dependent kinase (CDK)
• cyclin-dependent kinase-activating kinase (CAK)
• indolizines
• kinase inhibitors