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Miscellaneous

Carbamate-based reversible inhibitors of cathepsin S and cathepsin K

Pages 1077-1080 | Published online: 02 Mar 2005
 

Abstract

The preparation of a series of carbamate derivatives of dipeptide nitriles provides cathepsin inhibitors that, according to the P3 residue employed, are reported to selectively inhibit cathepsin S or cathepsin K. The resulting inhibitors are claimed to be useful in the treatment of autoimmune diseases or bone diseases, respectively.

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