Carbamate-based reversible inhibitors of cathepsin S and cathepsin K

Abstract

The preparation of a series of carbamate derivatives of dipeptide nitriles provides cathepsin inhibitors that, according to the P₃ residue employed, are reported to selectively inhibit cathepsin S or cathepsin K. The resulting inhibitors are claimed to be useful in the treatment of autoimmune diseases or bone diseases, respectively.

• cathepsin S inhibitor
• cathepsin K inhibitor
• multiple sclerosis (MS)
• osteoporosis
• rheumatoid arthritis